Anti-inflammatory properties of 5-hydroxypirimidine derivatives on the model of CFA-induced paw and ankle joint edema in rats

Anti-inflammatory potency of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) and SNK-578 (hydrochloride 2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) was evaluated on the model complete Freund`s adjuvant (CFA)-induced exudative inflammation in experiment 60 outbreed male rats weighing 180–200 g comparison with prednisolone. Prednisolone, were injected twice: 24 2 hours before injection CFA. Prednisolone administered dose 10 mg/kg, doses 25 mg/kg 40 mg/kg. Paw ankle joint edema registered after subplantar CFA right hind foot. administration decreased paw edema, paw, edema. Acquired data correlates previously obtained results that 5-hydroxypirimidine have antiallergenic effect systemic anaphylaxis guinea pigs.